Names & Taxonomy
- Uniprot ID:
- Q5VXI9
- Entry Name:
- LIPN_HUMAN
- Status:
- reviewed
- Protein Names:
- Lipase member N (EC 3.1.1.-) (Lipase-like abhydrolase domain-containing protein 4)
- Gene Names:
- LIPN LIPL4
- Gene Names Primary:
- LIPN
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 398
- Sequence:
- MMWLLLTTTCLICGTLNAGGFLDLENEVNPEVWMNTSEIIIYNGYPSEEYEVTTEDGYILLVNRIPYGRTHARSTGPRPVVYMQHALFADNAYWLENYANGSLGFLLADAGYDVWMGNSRGNTWSRRHKTLSETDEKFWAFSFDEMAKYDLPGVIDFIVNKTGQEKLYFIGHSLGTTIGFVAFSTMPELAQRIKMNFALGPTISFKYPTGIFTRFFLLPNSIIKAVFGTKGFFLEDKKTKIASTKICNNKILWLICSEFMSLWAGSNKKNMNQSRMDVYMSHAPTGSSVHNILHIKQLYHSDEFRAYDWGNDADNMKHYNQSHPPIYDLTAMKVPTAIWAGGHDVLVTPQDVARILPQIKSLHYFKLLPDWNHFDFVWGLDAPQRMYSEIIALMKAYS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted
Function
- Function:
- Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers.
- Active Site:
- ACT_SITE 173 173 Nucleophile.
- Gene Ontology Go:
- extracellular region
hydrolase activity, acting on ester bonds
lipid catabolic process
lipid digestion
small molecule metabolic process - Gene Ontology Biological Process:
- lipid catabolic process
lipid digestion
small molecule metabolic process - Gene Ontology Molecular Function:
- hydrolase activity, acting on ester bonds
- Gene Ontology Cellular Component:
- extracellular region
- Keywords:
- Complete proteome
Disulfide bond
Glycoprotein
Hydrolase
Ichthyosis
Lipid degradation
Lipid metabolism
Polymorphism
Reference proteome
Secreted
Signal