Names & Taxonomy

Uniprot ID:
Q5VTY9
Entry Name:
HHAT_HUMAN
Status:
reviewed
Protein Names:
Protein-cysteine N-palmitoyltransferase HHAT (EC 2.3.1.-) (Hedgehog acyltransferase) (Melanoma antigen recognized by T-cells 2) (MART-2) (Skinny hedgehog protein 1)
Gene Names:
HHAT MART2 SKI1
Gene Names Primary:
HHAT
Organism:
Homo sapiens (Human)

Structure

Length:
493
Sequence:
MLPRWELALYLLASLGFHFYSFYEVYKVSREHEEELDQEFELETDTLFGGLKKDATDFEWSFWMEWGKQWLVWLLLGHMVVSQMATLLARKHRPWILMLYGMWACWCVLGTPGVAMVLLHTTISFCVAQFRSQLLTWLCSLLLLSTLRLQGVEEVKRRWYKTENEYYLLQFTLTVRCLYYTSFSLELCWQQLPAASTSYSFPWMLAYVFYYPVLHNGPILSFSEFIKQMQQQEHDSLKASLCVLALGLGRLLCWWWLAELMAHLMYMHAIYSSIPLLETVSCWTLGGLALAQVLFFYVKYLVLFGVPALLMRLDGLTPPALPRCVSTMFSFTGMWRYFDVGLHNFLIRYVYIPVGGSQHGLLGTLFSTAMTFAFVSYWHGGYDYLWCWAALNWLGVTVENGVRRLVETPCIQDSLARYFSPQARRRFHAALASCSTSMLILSNLVFLGGNEVGKTYWNRIFIQGWPWVTLSVLGFLYCYSHVGIAWAQTYATD
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum membrane
Intramembrane:
INTRAMEM 95 119

Function

Function:
Catalyzes N-terminal palmitoylation of SHH; which is required for SHH signaling. May bind GTP.
Active Site:
ACT_SITE 379 379
Gene Ontology Go:
endoplasmic reticulum membrane
integral component of membrane
GTP binding
palmitoyltransferase activity
multicellular organism development
positive regulation of protein targeting to mitochondrion
protein palmitoylation
smoothened signaling pathway
Gene Ontology Biological Process:
multicellular organism development
positive regulation of protein targeting to mitochondrion
protein palmitoylation
smoothened signaling pathway
Gene Ontology Molecular Function:
GTP binding
palmitoyltransferase activity
Gene Ontology Cellular Component:
endoplasmic reticulum membrane
integral component of membrane
Keywords:
Acyltransferase
Alternative splicing
Complete proteome
Developmental protein
Endoplasmic reticulum
GTP-binding
Lipoprotein
Membrane
Nucleotide-binding
Palmitate
Polymorphism
Reference proteome
Transferase
Transmembrane
Transmembrane helix

Publication

PubMed ID:
11160356 14702039 17974005 16710414 15489334 11486055 25488661 25505265