Names & Taxonomy
- Uniprot ID:
- Q5T9L3
- Entry Name:
- WLS_HUMAN
- Status:
- reviewed
- Protein Names:
- Protein wntless homolog (Integral membrane protein GPR177) (Protein evenness interrupted homolog) (EVI) (Putative NF-kappa-B-activating protein 373)
- Gene Names:
- WLS C1orf139 GPR177 UNQ85/PRO18667
- Gene Names Orf:
- UNQ85/PRO18667
- Gene Names Primary:
- WLS
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 541
- Sequence:
- MAGAIIENMSTKKLCIVGGILLVFQIIAFLVGGLIAPGPTTAVSYMSVKCVDARKNHHKTKWFVPWGPNHCDKIRDIEEAIPREIEANDIVFSVHIPLPHMEMSPWFQFMLFILQLDIAFKLNNQIRENAEVSMDVSLAYRDDAFAEWTEMAHERVPRKLKCTFTSPKTPEHEGRYYECDVLPFMEIGSVAHKFYLLNIRLPVNEKKKINVGIGEIKDIRLVGIHQNGGFTKVWFAMKTFLTPSIFIIMVWYWRRITMMSRPPVLLEKVIFALGISMTFINIPVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFWIIFCGEHMMDQHERNHIAGYWKQVGPIAVGSFCLFIFDMCERGVQLTNPFYSIWTTDIGTELAMAFIIVAGICLCLYFLFLCFMVFQVFRNISGKQSSLPAMSKVRRLHYEGLIFRFKFLMLITLACAAMTVIFFIVSQVTEGHWKWGGVTVQVNSAFFTGIYGMWNLYVFALMFLYAPSHKNYGEDQSNGDLGVHSGEELQLTTTITHVDGPTEIYKLTRKEAQE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Golgi apparatus membrane
Function
- Function:
- Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity).
- Gene Ontology Go:
- cytoplasmic, membrane-bounded vesicle
dendrite cytoplasm
dendrite membrane
early endosome
early endosome membrane
endocytic vesicle membrane
endoplasmic reticulum membrane
extracellular exosome
Golgi apparatus
Golgi membrane
integral component of membrane
plasma membrane
trans-Golgi network
signal transducer activity
Wnt-protein binding
anterior/posterior axis specification
exocrine pancreas development
hindbrain development
intracellular protein transport
mesoderm formation
midbrain development
positive regulation of canonical Wnt signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of Wnt protein secretion
positive regulation of Wnt signaling pathway
Wnt signaling pathway - Gene Ontology Biological Process:
- anterior/posterior axis specification
exocrine pancreas development
hindbrain development
intracellular protein transport
mesoderm formation
midbrain development
positive regulation of canonical Wnt signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of Wnt protein secretion
positive regulation of Wnt signaling pathway
Wnt signaling pathway - Gene Ontology Molecular Function:
- signal transducer activity
Wnt-protein binding - Gene Ontology Cellular Component:
- cytoplasmic, membrane-bounded vesicle
dendrite cytoplasm
dendrite membrane
early endosome
early endosome membrane
endocytic vesicle membrane
endoplasmic reticulum membrane
extracellular exosome
Golgi apparatus
Golgi membrane
integral component of membrane
plasma membrane
trans-Golgi network - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Cytoplasmic vesicle
Developmental protein
Endoplasmic reticulum
Endosome
Golgi apparatus
Membrane
Polymorphism
Reference proteome
Signal
Transmembrane
Transmembrane helix
Wnt signaling pathway - Interacts With:
- P35372