Names & Taxonomy
- Uniprot ID:
- Q5T7S2
- Entry Name:
- Q5T7S2_HUMAN
- Status:
- unreviewed
- Protein Names:
- Receptor protein serine/threonine kinase (EC 2.7.11.30)
- Gene Names:
- TGFBR1 hCG_30154
- Gene Names Orf:
- hCG_30154
- Gene Names Primary:
- TGFBR1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 503
- Sequence:
- MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
Function
- Catalytic Activity:
- ATP + = ADP + phosphate.
- Gene Ontology Go:
- cell
integral component of membrane
intracellular
membrane
ATP binding
receptor signaling protein activity
receptor signaling protein serine/threonine kinase activity
transforming growth factor beta binding
transforming growth factor beta receptor activity, type I
activin receptor signaling pathway
cardiac epithelial to mesenchymal transition
endothelial cell activation
heart development
intracellular signal transduction
mesenchymal cell differentiation
positive regulation of endothelial cell proliferation
positive regulation of gene expression
positive regulation of transcription, DNA-templated
regulation of epithelial to mesenchymal transition
regulation of gene expression
transforming growth factor beta receptor signaling pathway - Gene Ontology Biological Process:
- activin receptor signaling pathway
cardiac epithelial to mesenchymal transition
endothelial cell activation
heart development
intracellular signal transduction
mesenchymal cell differentiation
positive regulation of endothelial cell proliferation
positive regulation of gene expression
positive regulation of transcription, DNA-templated
regulation of epithelial to mesenchymal transition
regulation of gene expression
transforming growth factor beta receptor signaling pathway - Gene Ontology Molecular Function:
- ATP binding
receptor signaling protein activity
receptor signaling protein serine/threonine kinase activity
transforming growth factor beta binding
transforming growth factor beta receptor activity, type I - Gene Ontology Cellular Component:
- cell
integral component of membrane
intracellular
membrane - Keywords:
- ATP-binding
Kinase
Membrane
Nucleotide-binding
Receptor
Serine/threonine-protein kinase
Signal
Transferase
Transmembrane
Transmembrane helix