Names & Taxonomy
- Uniprot ID:
- Q5JTZ9
- Entry Name:
- SYAM_HUMAN
- Status:
- reviewed
- Protein Names:
- Alanine--tRNA ligase, mitochondrial (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS)
- Gene Names:
- AARS2 AARSL KIAA1270
- Gene Names Primary:
- AARS2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 985
- Sequence:
- MAASVAAAARRLRRAIRRSPAWRGLSHRPLSSEPPAAKASAVRAAFLNFFRDRHGHRLVPSASVRPRGDPSLLFVNAGMNQFKPIFLGTVDPRSEMAGFRRVANSQKCVRAGGHHNDLEDVGRDLSHHTFFEMLGNWAFGGEYFKEEACNMAWELLTQVYGIPEERLWISYFDGDPKAGLDPDLETRDIWLSLGVPASRVLSFGPQENFWEMGDTGPCGPCTEIHYDLAGGVGAPQLVELWNLVFMQHNREADGSLQPLPQRHVDTGMGLERLVAVLQGKHSTYDTDLFSPLLNAIQQGCRAPPYLGRVGVADEGRTDTAYRVVADHIRTLSVCISDGIFPGMSGPPLVLRRILRRAVRFSMEILKAPPGFLGSLVPVVVETLGDAYPELQRNSAQIANLVSEDEAAFLASLERGRRIIDRTLRTLGPSDMFPAEVAWSLSLCGDLGLPLDMVELMLEEKGVQLDSAGLERLAQEEAQHRARQAEPVQKQGLWLDVHALGELQRQGVPPTDDSPKYNYSLRPSGSYEFGTCEAQVLQLYTEDGTAVASVGKGQRCGLLLDRTNFYAEQGGQASDRGYLVRAGQEDVLFPVARAQVCGGFILHEAVAPECLRLGDQVQLHVDEAWRLGCMAKHTATHLLNWALRQTLGPGTEQQGSHLNPEQLRLDVTTQTPLTPEQLRAVENTVQEAVGQDEAVYMEEVPLALTAQVPGLRSLDEVYPDPVRVVSVGVPVAHALDPASQAALQTSVELCCGTHLLRTGAVGDLVIIGDRQLSKGTTRLLAVTGEQAQQARELGQSLAQEVKAATERLSLGSRDVAEALRLSKDIGRLIEAVETAVMPQWQRRELLATVKMLQRRANTAIRKLQMGQAAKKTQELLERHSKGPLIVDTVSAESLSVLVKVVRQLCEQAPSTSVLLLSPQPMGKVLCACQVAQGAMPTFTAEAWALAVCSHMGGKAWGSRVVAQGTGSTTDLEAALSIAQTYALSQL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion
Function
- Function:
- Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
- Catalytic Activity:
- ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Cross Reference Drug Bank:
- DB00160
- Gene Ontology Go:
- mitochondrion
alanine-tRNA ligase activity
amino acid binding
ATP binding
metal ion binding
tRNA binding
gene expression
mitochondrial alanyl-tRNA aminoacylation
mitochondrial respiratory chain complex assembly
tRNA aminoacylation for protein translation
tRNA modification - Gene Ontology Biological Process:
- gene expression
mitochondrial alanyl-tRNA aminoacylation
mitochondrial respiratory chain complex assembly
tRNA aminoacylation for protein translation
tRNA modification - Gene Ontology Molecular Function:
- alanine-tRNA ligase activity
amino acid binding
ATP binding
metal ion binding
tRNA binding - Gene Ontology Cellular Component:
- mitochondrion
- Keywords:
- ATP-binding
Aminoacyl-tRNA synthetase
Cardiomyopathy
Complete proteome
Disease mutation
Ligase
Metal-binding
Mitochondrion
Nucleotide-binding
Polymorphism
Premature ovarian failure
Protein biosynthesis
RNA-binding
Reference proteome
Transit peptide
Zinc
tRNA-binding