Names & Taxonomy
- Uniprot ID:
- Q5IJ48
- Entry Name:
- CRUM2_HUMAN
- Status:
- reviewed
- Protein Names:
- Protein crumbs homolog 2 (Crumbs-like protein 2)
- Gene Names:
- CRB2
- Gene Names Primary:
- CRB2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1285
- Sequence:
- MALARPGTPDPQALASVLLLLLWAPALSLLAGTVPSEPPSACASDPCAPGTECQATESGGYTCGPMEPRGCATQPCHHGALCVPQGPDPTGFRCYCVPGFQGPRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEMEVDECASAPCLHGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVNGFRCDCAGTGYEGTHCEREVLECASAPCEHNASCLEGLGSFRCLCWPGYSGELCEVDEDECASSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADCGVEVDECASRPCLNGGHCQDLPNGFQCHCPDGYAGPTCEEDVDECLSDPCLHGGTCSDTVAGYICRCPETWGGRDCSVQLTGCQGHTCPLAATCIPIFESGVHSYVCHCPPGTHGPFCGQNTTFSVMAGSPIQASVPAGGPLGLALRFRTTLPAGTLATRNDTKESLELALVAATLQATLWSYSTTVLVLRLPDLALNDGHWHQVEVVLHLATLELRLWHEGCPARLCVASGPVALASTASATPLPAGISSAQLGDATFAGCLQDVRVDGHLLLPEDLGENVLLGCERREQCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCADEIPAATFGLGGAPSSASFLLQELPGPNLTVSFLLRTRESAGLLLQFANDSAAGLTVFLSEGRIRAEVPGSPAVVLPGRWDDGLRHLVMLSFGPDQLQDLGQHVHVGGRLLAADSQPWGGPFRGCLQDLRLDGCHLPFFPLPLDNSSQPSELGGRQSWNLTAGCVSEDMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQLWCPGQPCLPPATCEEVPDGFVCVAEATFREGPPAAFSGHNASSGRLLGGLSLAFRTRDSEAWLLRAAAGALEGVWLAVRNGSLAGGVRGGHGLPGAVLPIPGPRVADGAWHRVRLAMERPAATTSRWLLWLDGAATPVALRGLASDLGFLQGPGAVRILLAENFTGCLGRVALGGLPLPLARPRPGAAPGAREHFASWPGTPAPILGCRGAPVCAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRFECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCEANPCLNGGTCRAAGGVSECICNARFSGQFCEVAKGLPLPLPFPLLEVAVPAACACLLLLLLGLLSGILAARKRRQSEGTYSPSQQEVAGARLEMDSVLKVPPEERLI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Cell membrane; Single-pass type I membrane protein
Function
- Function:
- May play a role in polarized cells morphogenesis.
- Gene Ontology Go:
- extracellular exosome
integral component of membrane
membrane raft
plasma membrane
protein complex
calcium ion binding
enzyme binding
cardiovascular system development
maintenance of epithelial cell apical/basal polarity
mesoderm formation
negative regulation of endopeptidase activity
notochord formation
positive regulation of BMP signaling pathway
positive regulation of epithelial to mesenchymal transition
somitogenesis - Gene Ontology Biological Process:
- cardiovascular system development
maintenance of epithelial cell apical/basal polarity
mesoderm formation
negative regulation of endopeptidase activity
notochord formation
positive regulation of BMP signaling pathway
positive regulation of epithelial to mesenchymal transition
somitogenesis - Gene Ontology Molecular Function:
- calcium ion binding
enzyme binding - Gene Ontology Cellular Component:
- extracellular exosome
integral component of membrane
membrane raft
plasma membrane
protein complex - Keywords:
- 3D-structure
Alternative splicing
Calcium
Cell membrane
Complete proteome
Disease mutation
Disulfide bond
EGF-like domain
Glycoprotein
Membrane
Polymorphism
Reference proteome
Repeat
Secreted
Signal
Transmembrane
Transmembrane helix