Names & Taxonomy
- Uniprot ID:
- Q5H8A4
- Entry Name:
- PIGG_HUMAN
- Status:
- reviewed
- Protein Names:
- GPI ethanolamine phosphate transferase 2 (EC 2.-.-.-) (GPI7 homolog) (hGPI7) (Phosphatidylinositol-glycan biosynthesis class G protein) (PIG-G)
- Gene Names:
- PIGG GPI7 UNQ1930/PRO4405
- Gene Names Orf:
- UNQ1930/PRO4405
- Gene Names Primary:
- PIGG
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 983
- Sequence:
- MRLGSGTFATCCVAIEVLGIAVFLRGFFPAPVRSSARAEHGAEPPAPEPSAGASSNWTTLPPPLFSKVVIVLIDALRDDFVFGSKGVKFMPYTTYLVEKGASHSFVAEAKPPTVTMPRIKALMTGSLPGFVDVIRNLNSPALLEDSVIRQAKAAGKRIVFYGDETWVKLFPKHFVEYDGTTSFFVSDYTEVDNNVTRHLDKVLKRGDWDILILHYLGLDHIGHISGPNSPLIGQKLSEMDSVLMKIHTSLQSKERETPLPNLLVLCGDHGMSETGSHGASSTEEVNTPLILISSAFERKPGDIRHPKHVQQTDVAATLAIALGLPIPKDSVGSLLFPVVEGRPMREQLRFLHLNTVQLSKLLQENVPSYEKDPGFEQFKMSERLHGNWIRLYLEEKHSEVLFNLGSKVLRQYLDALKTLSLSLSAQVAQYDIYSMMVGTVVVLEVLTLLLLSVPQALRRKAELEVPLSSPGFSLLFYLVILVLSAVHVIVCTSAESSCYFCGLSWLAAGGVMVLASALLCVIVSVLTNVLVGGNTPRKNPMHPSSRWSELDLLILLGTAGHVLSLGASSFVEEEHQTWYFLVNTLCLALSQETYRNYFLGDDGEPPCGLCVEQGHDGATAAWQDGPGCDVLERDKGHGSPSTSEVLRGREKWMVLASPWLILACCRLLRSLNQTGVQWAHRPDLGHWLTSSDHKAELSVLAALSLLVVFVLVQRGCSPVSKAALALGLLGVYCYRAAIGSVRFPWRPDSKDISKGIIEARFVYVFVLGILFTGTKDLLKSQVIAADFKLKTVGLWEIYSGLVLLAALLFRPHNLPVLAFSLLIQTLMTKFIWKPLRHDAAEITVMHYWFGQAFFYFQGNSNNIATVDISAGFVGLDTYVEIPAVLLTAFGTYAGPVLWASHLVHFLSSETRSGSALSHACFCYALICSIPVFTYIVLVTSLRYHLFIWSVFSPKLLYEGMHLLITAAVCVFFTAMDQTRLTQS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.
- Pathway:
- Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.
- Gene Ontology Go:
- endoplasmic reticulum
endoplasmic reticulum membrane
integral component of endoplasmic reticulum membrane
membrane
CP2 mannose-ethanolamine phosphotransferase activity
phosphotransferase activity, for other substituted phosphate groups
C-terminal protein lipidation
cellular protein metabolic process
GPI anchor biosynthetic process
post-translational protein modification
preassembly of GPI anchor in ER membrane - Gene Ontology Biological Process:
- cellular protein metabolic process
C-terminal protein lipidation
GPI anchor biosynthetic process
post-translational protein modification
preassembly of GPI anchor in ER membrane - Gene Ontology Molecular Function:
- CP2 mannose-ethanolamine phosphotransferase activity
phosphotransferase activity, for other substituted phosphate groups - Gene Ontology Cellular Component:
- endoplasmic reticulum
endoplasmic reticulum membrane
integral component of endoplasmic reticulum membrane
membrane - Keywords:
- Alternative splicing
Complete proteome
Endoplasmic reticulum
GPI-anchor biosynthesis
Glycoprotein
Membrane
Polymorphism
Reference proteome
Transferase
Transmembrane
Transmembrane helix