Names & Taxonomy
- Uniprot ID:
- A0A024R1C2
- Entry Name:
- A0A024R1C2_HUMAN
- Status:
- unreviewed
- Protein Names:
- DNA topoisomerase (EC 5.99.1.2)
- Gene Names:
- TOP3B hCG_2010987
- Gene Names Orf:
- hCG_2010987
- Gene Names Primary:
- TOP3B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 862
- Sequence:
- MKTVLMVAEKPSLAQSIAKILSRGSLSSHKGLNGACSVHEYTGTFAGQPVRFKMTSVCGHVMTLDFLGKYNKWDKVDPAELFSQAPTEKKEANPKLNMVKFLQVEGRGCDYIVLWLDCDKEGENICFEVLDAVLPVMNKAHGGEKTVFRARFSSITDTDICNAMACLGEPDHNEALSVDARQELDLRIGCAFTRFQTKYFQGKYGDLDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNTDKDRSLLLDWDRVRVFDREIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAERLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADTVKRLLAEGINRPRKGHDAGDHPPITPMKSATEAELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLSPGFTEVMPWQSVPLEESLPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLMEKHGIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEKQLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGKCHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRGKSYPLCPYCYNHPPFRDMKKGMGCNECTHPSCQHSLSMLGIGQCVECESGVLVLDPTSGPKWKVACNKCNVVAHCFENAHRVRVSADTCSVCEAALLDVDFNKAKSPLPGDETQHMGCVFCDPVFQELVELKHAASCHPMHRGGPGRRQGRGRGRARRPPGKPNPRRPKDKMSALAAYFV
Function
- Function:
- Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.
- Catalytic Activity:
- ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.
- Gene Ontology Go:
- condensed chromosome
nucleus
DNA binding
DNA topoisomerase type I activity
chromosome segregation
DNA topological change - Gene Ontology Biological Process:
- chromosome segregation
DNA topological change - Gene Ontology Molecular Function:
- DNA binding
DNA topoisomerase type I activity - Gene Ontology Cellular Component:
- condensed chromosome
nucleus - Keywords:
- DNA-binding
Isomerase
Topoisomerase
Publication
- PubMed ID:
- 11181995