Names & Taxonomy

Uniprot ID:
Q4U2R8
Entry Name:
S22A6_HUMAN
Status:
reviewed
Protein Names:
Solute carrier family 22 member 6 (Organic anion transporter 1) (hOAT1) (PAH transporter) (hPAHT) (Renal organic anion transporter 1) (hROAT1)
Gene Names:
SLC22A6 OAT1 PAHT
Gene Names Primary:
SLC22A6
Organism:
Homo sapiens (Human)

Structure

Length:
563
Sequence:
MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRWAPTQKEAGIYPRKGKQTRQQQEHQKYMVPLQASAQEKNGL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-independent uptake of p-aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3'-azido-3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF), cidofovir, adefovir, 9-(2-phosphonylmethoxyethyl) guanine (PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate. PAH uptake is inhibited by p-chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), sulindac, diclofenac, carprofen, glutarate and okadaic acid (By similarity). PAH uptake is inhibited by benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, furosemide, indomethacin, bumetamide, losartan, probenecid, phenol red, urate, and alpha-ketoglutarate.
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=9.3 uM for PAH (isoform 1)
Cross Reference Drug Bank:
DB00316 DB00819 DB06151 DB00945 DB00787 DB00718 DB00345 DB01424 DB01060 DB01435 DB00168 DB01053 DB01237 DB00887 DB01197 DB00578 DB00821 DB00520 DB01414 DB01140 DB00456 DB01326 DB01327 DB01329 DB00493 DB00229 DB01333 DB00438 DB01212 DB00567 DB00446 DB00880 DB00672 DB00369 DB01597 DB00501 DB00827 DB01147 DB00286 DB00091 DB00606 DB08912 DB00586 DB00900 DB00861 DB01160 DB00917 DB00254 DB00584 DB00903 DB00749 DB00693 DB00712 DB00158 DB00529 DB00695 DB01004 DB00798 DB01016 DB00999 DB01050 DB00328 DB01009 DB00709 DB01137 DB00678 DB00939 DB00703 DB00563 DB01017 DB00607 DB00779 DB00788 DB00731 DB01059 DB01051 DB01165 DB00595 DB00812 DB00319 DB00554 DB00175 DB01032 DB00140 DB00936 DB00649 DB01082 DB00605 DB00300 DB00759 DB01124 DB00500 DB00432 DB00577 DB00313 DB00512 DB00943 DB00495
Gene Ontology Go:
basolateral plasma membrane
caveola
extracellular exosome
integral component of plasma membrane
plasma membrane
protein complex
chloride ion binding
inorganic anion exchanger activity
organic anion transmembrane transporter activity
sodium-independent organic anion transmembrane transporter activity
alpha-ketoglutarate transport
anion transmembrane transport
organic anion transport
protein homooligomerization
renal tubular secretion
response to methotrexate
sodium-independent organic anion transport
transmembrane transport
Gene Ontology Biological Process:
alpha-ketoglutarate transport
anion transmembrane transport
organic anion transport
protein homooligomerization
renal tubular secretion
response to methotrexate
sodium-independent organic anion transport
transmembrane transport
Gene Ontology Molecular Function:
chloride ion binding
inorganic anion exchanger activity
organic anion transmembrane transporter activity
sodium-independent organic anion transmembrane transporter activity
Gene Ontology Cellular Component:
basolateral plasma membrane
caveola
extracellular exosome
integral component of plasma membrane
plasma membrane
protein complex
Keywords:
Alternative splicing
Cell membrane
Complete proteome
Glycoprotein
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Interacts With:
Q92624

Publication

PubMed ID:
9762842 9887087 9950961 10049739 10462545 10964714 16554811 15489334 12538807 14749323 15145940 15644426 15846473 17038320 17502342 15914676 16164626