Names & Taxonomy
- Uniprot ID:
- Q4KMQ2
- Entry Name:
- ANO6_HUMAN
- Status:
- reviewed
- Protein Names:
- Anoctamin-6 (Small-conductance calcium-activated nonselective cation channel) (SCAN channel) (Transmembrane protein 16F)
- Gene Names:
- ANO6 TMEM16F
- Gene Names Primary:
- ANO6
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 910
- Sequence:
- MKKMSRNVLLQMEEEEDDDDGDIVLENLGQTIVPDLGSLESQHDFRTPEFEEFNGKPDSLFFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQARPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITPRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNMGVIAERMIEAVDNNLRPKSE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.
- Enzyme Regulation:
- ENZYME REGULATION: Exhibits synergistic gating by Ca(2+) and voltage. Inhibited by some non-specific cation channel blockers such as: ruthenium red, 2-aminoethyl diphenylborinate (2APB), gadolinium and cadmium ions (By similarity).
- Gene Ontology Go:
- cell surface
chloride channel complex
extracellular exosome
intracellular
membrane
plasma membrane
calcium activated cation channel activity
intracellular calcium activated chloride channel activity
phospholipid scramblase activity
voltage-gated chloride channel activity
voltage-gated ion channel activity
activation of blood coagulation via clotting cascade
bleb assembly
blood coagulation
bone mineralization involved in bone maturation
calcium activated galactosylceramide scrambling
calcium activated phosphatidylcholine scrambling
calcium activated phosphatidylserine scrambling
calcium ion transmembrane transport
cation transport
chloride transmembrane transport
chloride transport
dendritic cell chemotaxis
ion transmembrane transport
negative regulation of cell volume
phosphatidylserine exposure on blood platelet
phospholipid scrambling
pore complex assembly
positive regulation of apoptotic process
positive regulation of bone mineralization
positive regulation of endothelial cell apoptotic process
positive regulation of ion transmembrane transport
positive regulation of monocyte chemotaxis
positive regulation of phagocytosis, engulfment
purinergic nucleotide receptor signaling pathway
regulation of anion transmembrane transport
sodium ion transmembrane transport
transmembrane transport - Gene Ontology Biological Process:
- activation of blood coagulation via clotting cascade
bleb assembly
blood coagulation
bone mineralization involved in bone maturation
calcium activated galactosylceramide scrambling
calcium activated phosphatidylcholine scrambling
calcium activated phosphatidylserine scrambling
calcium ion transmembrane transport
cation transport
chloride transmembrane transport
chloride transport
dendritic cell chemotaxis
ion transmembrane transport
negative regulation of cell volume
phosphatidylserine exposure on blood platelet
phospholipid scrambling
pore complex assembly
positive regulation of apoptotic process
positive regulation of bone mineralization
positive regulation of endothelial cell apoptotic process
positive regulation of ion transmembrane transport
positive regulation of monocyte chemotaxis
positive regulation of phagocytosis, engulfment
purinergic nucleotide receptor signaling pathway
regulation of anion transmembrane transport
sodium ion transmembrane transport
transmembrane transport - Gene Ontology Molecular Function:
- calcium activated cation channel activity
intracellular calcium activated chloride channel activity
phospholipid scramblase activity
voltage-gated chloride channel activity
voltage-gated ion channel activity - Gene Ontology Cellular Component:
- cell surface
chloride channel complex
extracellular exosome
intracellular
membrane
plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Chloride
Chloride channel
Complete proteome
Glycoprotein
Ion channel
Ion transport
Lipid transport
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel