Names & Taxonomy

Uniprot ID:
Q4G7F8
Entry Name:
Q4G7F8_HUMAN
Status:
unreviewed
Protein Names:
Cytochrome c oxidase subunit 1 (EC 1.9.3.1)
Gene Names:
COI COX1
Gene Names Primary:
COI
Organism:
Homo sapiens (Human)

Structure

Length:
513
Sequence:
MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQPGNLLGNDHIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLASAMVETGAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKWSAAVLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFIHWFPLFSGYTLDQTYAKIHFTIMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTWNILSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSMNLEWLYGCPPPYHTFEEPVYMKS

Subcellular location

Subcellular Location:
Mitochondrion inner membrane
Gene Encoded:
Mitochondrion

Function

Function:
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
Pathway:
Energy metabolism; oxidative phosphorylation.
Catalytic Activity:
4 ferrocytochrome c + O(2) + 4 H(+) = 4 ferricytochrome c + 2 H(2)O.
Gene Ontology Go:
integral component of membrane
mitochondrial inner membrane
respiratory chain
cytochrome-c oxidase activity
heme binding
iron ion binding
aerobic respiration
oxidative phosphorylation
Gene Ontology Biological Process:
aerobic respiration
oxidative phosphorylation
Gene Ontology Molecular Function:
cytochrome-c oxidase activity
heme binding
iron ion binding
Gene Ontology Cellular Component:
integral component of membrane
mitochondrial inner membrane
respiratory chain
Keywords:
Copper
Electron transport
Heme
Iron
Membrane
Metal-binding
Mitochondrion
Mitochondrion inner membrane
Oxidoreductase
Respiratory chain
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
11938495 15466285 16172508 16901986 17517629 19083815 18477584 18446216 19133286 21176127 20513740 20808834 21203537 21978175 21041797 21822691 22482806 22560092 22258525 22130972 22130971 22729749 24323467 23844106 24244704 24341918 24607387 24726474 25301575 24863938 25254093 24676463 24901532 25738654 26509580