Names & Taxonomy
- Uniprot ID:
- Q3SY69
- Entry Name:
- AL1L2_HUMAN
- Status:
- reviewed
- Protein Names:
- Mitochondrial 10-formyltetrahydrofolate dehydrogenase (Mitochondrial 10-FTHFDH) (mtFDH) (EC 1.5.1.6) (Aldehyde dehydrogenase family 1 member L2)
- Gene Names:
- ALDH1L2
- Gene Names Primary:
- ALDH1L2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 923
- Sequence:
- MLRRGSQALRRFSTGRVYFKNKLKLALIGQSLFGQEVYSHLRKEGHRVVGVFTVPDKDGKADPLALAAEKDGTPVFKLPKWRVKGKTIKEVAEAYRSVGAELNVLPFCTQFIPMDIIDSPKHGSIIYHPSILPRHRGASAINWTLIMGDKKAGFSVFWADDGLDTGPILLQRSCDVEPNDTVDALYNRFLFPEGIKAMVEAVQLIADGKAPRIPQPEEGATYEGIQKKENAEISWDQSAEVLHNWIRGHDKVPGAWTEINGQMVTFYGSTLLNSSVPPGEPLEIKGAKKPGLVTKNGLVLFGNDGKALTVRNLQFEDGKMIPASQYFSTGETSVVELTAEEVKVAETIKVIWAGILSNVPIIEDSTDFFKSGASSMDVARLVEEIRQKCGGLQLQNEDVYMATKFEGFIQKVVRKLRGEDQEVELVVDYISKEVNEIMVKMPYQCFINGQFTDADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAAKDAFENGEWGRMNARERGRLMYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQGSTIPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPLTALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSCAVSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHDEFVTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGGRQVQRPGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLASGVFTRDINKAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSGFGKDLGEEALNEYLKTKTVTLEY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion
Function
- Catalytic Activity:
- 10-formyltetrahydrofolate + NADP(+) + H(2)O = tetrahydrofolate + CO(2) + NADPH.
- Active Site:
- ACT_SITE 128 128 Proton donor.
- Gene Ontology Go:
- extracellular exosome
mitochondrion
4-trimethylammoniobutyraldehyde dehydrogenase activity
aminobutyraldehyde dehydrogenase activity
formyltetrahydrofolate dehydrogenase activity
hydroxymethyl-, formyl- and related transferase activity
10-formyltetrahydrofolate catabolic process
biosynthetic process
one-carbon metabolic process - Gene Ontology Biological Process:
- 10-formyltetrahydrofolate catabolic process
biosynthetic process
one-carbon metabolic process - Gene Ontology Molecular Function:
- 4-trimethylammoniobutyraldehyde dehydrogenase activity
aminobutyraldehyde dehydrogenase activity
formyltetrahydrofolate dehydrogenase activity
hydroxymethyl-, formyl- and related transferase activity - Gene Ontology Cellular Component:
- extracellular exosome
mitochondrion - Keywords:
- Acetylation
Alternative splicing
Complete proteome
Mitochondrion
NADP
One-carbon metabolism
Oxidoreductase
Phosphopantetheine
Phosphoprotein
Reference proteome
Transit peptide